Systemic sclerosis & Raynaud's
Metabolomic Differences in Connective Tissue Disease–Associated Versus Idiopathic Pulmonary Arterial Hypertension in the PVDOMICS Cohort
Authors' conclusion
CTD-PAH is characterized by aberrant lipid metabolism that may signal shifted metabolic substrate utilization.
Study context
- Population
- Adults with CTD-PAH or idiopathic PAH (IPAH) from the PVDOMICS study115 with paired samples
- Participants
- 141 vs 165
- Exposure
- CTD-PAH vs IPAH
- CTD-PAHn = 141
- IPAHn = 165reference
- Outcome
- Differential metabolomic profiles of plasma, CTD-PAH vs IPAH
Methodological detailsmetabolomic profiling, machine learning, paired mixed venous and wedged samples in a subset
- Metabolomic profiling
- Machine learning
- Paired mixed venous and wedged samples in a subset
Main finding
As reported in the abstract
Plasma metabolomic profiles
- Metabolomic profiles distinguished CTD-PAH from IPAH
- CTD-PAH: aberrant lipid metabolism with lower sex steroid hormones and higher free fatty acids (FAs) and FA intermediates
Observational data: associations, not effects.
Further findings
Metabolite gradients across the right ventricular-pulmonary vascular (RV-PV) circulation
- Acylcholines taken up by the RV-PV circulation, particularly in CTD-PAH; free FAs and acylcarnitines released
Metabolite-phenotype associations
- In both subtypes, dysregulated lipid metabolites associated with hemodynamic and RV measurements and transplant-free survival
Original publication
Metabolomic Differences in Connective Tissue Disease–Associated Versus Idiopathic Pulmonary Arterial Hypertension in the PVDOMICS Cohort. Arthritis Rheumatol. Published 30 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →