Systemic sclerosis & Raynaud's
Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study
Main finding · Incident bronchiectasisResult — go to the resultAdjusted hazard ratio 2.63 95% CI 2.22–3.12Authors' conclusion
The risk of incident bronchiectasis is higher in individuals with systemic sclerosis than those without.
Study context
- Population
- Korean National Health Insurance Service dataset, 2010–2017: adults aged ≥ 20 years with SSc and age- and sex-matched individuals without SScmedian follow-up 6.0 years
- Participants
- 4,845 vs 24,225
- Exposure
- SSc vs matched individuals without SSc
- SScn = 4,845
- Matchedn = 24,225reference
- Outcome
- Incident bronchiectasis
Methodological detailsnationwide, longitudinal, matched 1:5 by age and sex
- Nationwide
- Longitudinal
- Matched 1:5 by age and sex
Main finding
As reported in the abstract
median follow-up 6.0 (IQR 3.2-8.7) years
Adjusted hazard ratio
2.63
95% CI 2.22–3.12
By group
SScvs Matched
aHR 2.63 (95% CI 2.22–3.12)
Observational data: associations, not effects.
Further findings
Incident bronchiectasis within SSc by age (subgroup): higher risk in those aged 20-39 years
- Risk notably higher in younger individuals aged 20-39 years than counterparts
- P for interaction = 0.048
Incident bronchiectasis within SSc by coexisting connective tissue disease (subgroup)
- Risk notably higher in those without other coexisting connective tissue diseases than counterparts
- P for interaction = 0.006
Original publication
Systemic sclerosis and risk of bronchiectasis: a nationwide longitudinal cohort study. Arthritis Res Ther. Published 23 October 2023. doi:10.
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