Systemic sclerosis & Raynaud's
Cancer Risk in Patients With Systemic Sclerosis: A Nationwide Cohort Study in South Korea 2004 to 2021
Main finding · Overall cancerResult — go to the resultStandardized incidence ratio 3.12 95% CI 2.92–3.33Authors' conclusion
In this study, we revealed that the incidence of cancer is higher in patients with SSc in South Korea compared to the general population.
Study context
- Population
- Patients newly diagnosed with systemic sclerosis (SSc) between 2004 and 2020, Korean National Health Insurance Service (80.2% women; mean ± SD age at diagnosis 53.1 ± 13.4 years)
- Participants
- 6,386 patients
- Exposure
- Patients with SSc vs the general population
- SScn = 6,386
- Outcome
- Overall and site-specific cancer risk (SIR) vs the general population
Methodological detailsstandardized incidence ratios vs general population, Korean National Health Insurance Service data
- Standardized incidence ratios vs general population
- Korean National Health Insurance Service data
Main finding
Overall cancer
Standardized incidence ratio
3.12
95% CI 2.92–3.33
SScvs General population
SIR 3.12 (95% CI 2.92–3.33)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | SIR (95% CI) | |
|---|---|---|
| Solid cancer | 3.07 (2.86–3.28) | |
| Hematologic cancer | 5.70 (4.50–7.11) | |
| 0.10.31310Standardized incidence ratio (log scale) |
Myelodysplastic syndrome (highest site-specific risk)
- SIR
- 12.52 (95% CI 7.00-20.65)
- Followed by multiple myeloma, eye, Hodgkin lymphoma, and larynx cancers
Cancer risk by age at diagnosis: peak at age 20 to 39 years (subgroup)
- SIR
- 5.27 (95% CI 4.31-6.38)
Cancer risk by follow-up duration: peak during first year after diagnosis (subgroup)
- SIR
- 4.44 (95% CI 3.81-5.14)
Original publication
Cancer Risk in Patients With Systemic Sclerosis: A Nationwide Cohort Study in South Korea 2004 to 2021. Arthritis Care Res (Hoboken). Published 23 September 2025. doi:10.
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