Systemic sclerosis & Raynaud's
Association of SSc with risk of premature ovarian insufficiency: a retrospective cohort study
Main finding · POIResult — go to the resultHazard ratio 1.6 95% CI 1.1–2.2Authors' conclusion
Our study indicates that SSc is associated with a 1.6 times higher risk of developing POI.
Study context
- Population
- Females aged 20–40 with and without SSc, Collaborative EHR Network, worldwide, 2005 to 2022matched cohort 1:1
- Participants
- 6,417 vs 6,417
- Exposure
- SSc vs matched non-SSc
- SScn = 6,417
- Non-SScn = 6,417reference
- Outcome
- Incident POI
Methodological detailspropensity-score matched (1:1)
- Propensity-score matched (1:1)
Main finding
POI
Hazard ratio
1.6
95% CI 1.1–2.2
log-rank test P = 0.017
SScvs Non-SSc
HR 1.6 (95% CI 1.1–2.2); log-rank test P = 0.017
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| POI, SSc aged 30-40 (subgroup) | 1.8 (1.2–2.8) | |
| 0.20.5125Hazard ratio (log scale) |
Premature ovarian insufficiency (POI), by race (white and black)
- This association was consistent across both white and black populations
Original publication
Association of SSc with risk of premature ovarian insufficiency: a retrospective cohort study. Rheumatology (Oxford). Published 17 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →