Systemic sclerosis & Raynaud's
Evaluating unsupervised and rule-based phenotyping methods versus administrative code counts for systemic sclerosis identification
Authors' conclusion
M34 code counts achieved reasonable performance for SSc identification and comparable to those of LPC and PheRS. However, both LPC and PheRS demonstrated better performance for predicting mortality compared with M34 code counts in patients with SSc.
Study context
- Population
- Patients with at least one M34 code in the electronic health record (EHR) of a single centre; rheumatologist-diagnosed systemic sclerosis (SSc) as reference547 (84%) with rheumatologist-diagnosed SSc
- Participants
- 653 patients
- Comparison
- LPC vs phenotype risk score (PheRS) vs M34 International Classification of Disease (ICD) code counts for identifying SSc and predicting mortality from EHR
- Outcome
- Identification of rheumatologist-diagnosed SSc and prediction of mortality
Methodological detailssingle-centre, retrospective
- Single-centre
- Retrospective
Performance
As reported in the abstract
Distinguishing rheumatologist-diagnosed SSc from M34 non-SSc controls (individuals with ≥1 M34 code)
| Test or model | AUROC |
|---|---|
| LPC | 0.72 |
| PheRS | 0.70 |
| M34 ICD code counts | 0.70 |
AUROC
LPC0.72
PheRS0.70
M34 ICD code counts0.70
Further findings
| Outcome | LPC | PheRS | M34 code counts |
|---|---|---|---|
| Distinguishing rheumatologist-diagnosed SSc from M34 non-SSc controls, among individuals with ≥1 M34 code (AUROC) | |||
| AUROC | 0.72 | 0.70 | 0.70 |
| Predicting mortality in patients with SSc (AUROC) | |||
| AUROC | 0.74 | 0.72 | 0.63 |
Distinguishing rheumatologist-diagnosed SSc from M34 non-SSc controls, among individuals with ≥1 M34 code (AUROC)
- LPC only marginally superior to PheRS and M34 code counts
Identifying SSc using ≥2 M34 codes
- Sensitivity of ≥2 M34 codes
- 87.8%
- PPV of ≥2 M34 codes
- 87.0%
Original publication
Evaluating unsupervised and rule-based phenotyping methods versus administrative code counts for systemic sclerosis identification. Semin Arthritis Rheum. Published 29 June 2026. doi:10.
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