Lupus & antiphospholipid syndrome
Renal arteriosclerosis in kidney biopsies associated with higher 10-year atherosclerotic cardiovascular disease in lupus nephritis
An erratum to this article was published (Rheumatology (Oxford), 1 Aug 2025 ↗)
Authors' conclusion
Renal arteriosclerosis >25%, area deprivation and ACEi exposure could inform ASCVD risk stratification in LN.
Study context
- Population
- Adults with biopsy-proven lupus nephritis (LN)
- Participants
- 209 adults
- Exposure
- Renal arteriosclerosis >25% in kidney biopsies at LN diagnosis vs lesser arteriosclerosis
- Outcome
- Clinical ASCVD (fatal and non-fatal events, adjudicated)
- Follow-up
- 10 years
Methodological detailsbiopsies re-read with standard Banff grading criteria, Cox models
- Biopsies re-read with standard Banff grading criteria
- Cox models
Main finding
As reported in the abstract
10-year clinical ASCVD
- 36 clinical atherosclerotic cardiovascular disease (ASCVD) events within 10 years
- Renal arteriosclerosis (>25%) associated with 3× higher 10-year ASCVD
- High area deprivation index (>80) associated with 4× higher ASCVD occurrence
- Longer angiotensin converting enzyme inhibitor (ACEi) exposure associated with 0.65× lower ASCVD occurrence
- Adding renal arteriosclerosis >25% improved model performance for 10-year ASCVD risk estimation from 65% to 80%
Observational data: associations, not effects.
Further findings
- 49 clinical ASCVD events within 20 years
- Similar associations seen with 20-year ASCVD
Original publication
Renal arteriosclerosis in kidney biopsies associated with higher 10-year atherosclerotic cardiovascular disease in lupus nephritis. Rheumatology (Oxford). Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →