Lupus & antiphospholipid syndrome
Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement
Authors' conclusion
Levels of NETs were increased in quiescent SLE patients. Although free thiol levels did not differ among the groups. The levels of NETs and free thiols were independently associated in SLE patients, suggesting a potential role of OS in NETs formation.
Study context
- Population
- Quiescent systemic lupus erythematosus (SLE) patients (SLEDAI < 5) with and without renal involvement, and healthy controls100 SLE patients · 22 healthy controls (HCs)
- Participants
- 73 / 27 / 22
- Exposure
- SLE without renal involvement vs lupus nephritis (LN) vs healthy controls
- non-LNn = 73
- LNn = 27
- HCsn = 22reference
- Outcome
- Plasma levels of NETs (myeloperoxidase-DNA complex ELISA) and free thiols (systemic oxidative stress), and their relationship
Main finding
As reported in the abstract
Correlation of neutrophil extracellular traps (NETs) with free thiols, all 100 SLE patients (rho)
−0.32
Correlation of NETs with free thiols, non-LN (rho)
−0.38
Observational data: associations, not effects.
Further findings
Free thiol levels in subgroups
- Significantly lower free thiols with estimated glomerular filtration rate (eGFR) < 60, serum creatinine (sCr) ≥ 90, C reactive protein (CRP) ≥ 5 and body mass index (BMI) ≥ 30
Independent associations with free thiol levels (multivariable regression)
- Disease duration, NETs levels and eGFR independently associated with free thiol levels
Original publication
Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement. Arthritis Res Ther. Published 19 December 2024. doi:10.
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