Lupus & antiphospholipid syndrome
KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus
Authors' conclusion
KLF2 controls the apoptosis of neutrophils and is associated with SLEDAI
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls; neutrophils
- Comparison
- SLE patients vs healthy controls (HCs)
- Outcome
- Role of KLF2 in regulation of neutrophil apoptosis and its association with SLE disease activity
Main finding
As reported in the abstract
- KLF2 expression in neutrophils of SLE patients significantly suppressed; decreased KLF2 associated with upregulation of neutrophil apoptosis
- Newly diagnosed SLE, SLE with higher serum IgG and positive anti-Smith antibodies had lower KLF2 expression
- Modulating KLF2 expression can regulate neutrophil apoptosis
- Neutrophil KLF2 levels associated with SLE disease activity index (SLEDAI)
- Serum from SLE patients induced neutrophil apoptosis by down-regulating KLF2
Original publication
KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus. Arthritis Res Ther. Published 19 December 2024. doi:10.
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