Lupus & antiphospholipid syndrome
Large overlap in neutrophil transcriptome between lupus and COVID-19 with limited lupus-specific gene expression
Authors' conclusion
The substantial overlap between neutrophil responses in SLE and COVID-19 suggests that the unknown cause of SLE is functionally similar to a viral infection and drives a similar immune activation and type I interferon response.
Study context
- Population
- Neutrophils from patients with SLE, patients with SARS-CoV-2 infection and healthy controlstwo datasets
- Participants
- 15 / 12 / 30 / 8
- Comparison
- SLE neutrophils vs healthy controls, compared with SARS-CoV-2 neutrophils vs healthy controls
- SLEn = 15
- Healthy controls (SLE dataset)n = 12reference
- SARS-CoV-2n = 30
- Healthy controls (SARS-CoV-2 dataset)n = 8reference
- Outcome
- Differentially expressed genes in SLE neutrophils vs healthy donor neutrophils (≥2 fold, p<0.05)
Methodological detailsRNA sequencing, comparative transcriptomic analysis
- RNA sequencing
- Comparative transcriptomic analysis
Main finding
As reported in the abstract
Differentially expressed genes in SLE vs healthy donor neutrophils
372
Concordant with transcriptional changes in SARS-CoV-2-infected individuals vs their healthy controls
181
Genes with significant alterations exclusive to SLE
118
Genes differentially expressed in opposite directions in the two diseases
28
Original publication
Large overlap in neutrophil transcriptome between lupus and COVID-19 with limited lupus-specific gene expression. Lupus Sci Med. Published 31 January 2024. doi:10.
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