Lupus & antiphospholipid syndrome
Improving the arthritis component of the SLEDAI-2K
Study context
- Population
- SLE patients with inflammatory joint pain (swelling not required)78 with SLEDAI-2K arthritis
- Participants
- 133 patients
- Comparison
- SLEDAI arthritis scored for clinician-observed swelling vs scored without observed swelling, tested against US
- Observed swellingn = 57
- Without observed swellingn = 21
- Primary endpoint
- Abnormal US (PPV) for SLEDAI arthritis definitions
Methodological detailsassessors blinded to ultrasound, ROC analysis
- Assessors blinded to ultrasound
- ROC analysis
Primary result
As reported in the abstract
Abnormal US among patients scored for SLEDAI arthritis
| Group | Value | PPV | 95% CI |
|---|---|---|---|
| Observed swelling | 90% | 90% | 79, 94 |
| Without observed swelling | 48% | 48% | 31, 67 |
Value
Observed swelling90%
Without observed swelling48%
PPV
Observed swelling90%
Without observed swelling48%
95% CI
Observed swelling79, 94
Without observed swelling31, 67
Further findings
Clinical and laboratory variables
- Patients with SLEDAI arthritis with swelling had higher ESR, physician MSK-VAS, patient EMS-VAS and IgG vs other patients
Optimal swollen joint count threshold for US synovitis (Youden's criteria)
- Optimal sensitivity and specificity
- 1 swollen joint
Scoring for warmth or erythema alone
- No patient was scored for warmth or erythema alone
Original publication
Improving the arthritis component of the SLEDAI-2K. Rheumatology (Oxford). Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →