Spondyloarthritis & psoriatic arthritis
Radiographic sacroiliitis progression in psoriatic arthritis
Authors' conclusion
Radiographic sacroiliitis progression is common in PsA. Greater inflammatory activity increased risk, whereas b/tsDMARD exposure were protective; progression was lower in the modern treatment era.
Study context
- Population
- Patients with PsA in a prospective cohort (1978–2025), excluding those with sacroiliitis sum score (SSS) = 8 at baselinemedian follow-up 6.00 years
- Participants
- 1,554 patients
- Outcome
- Change in sacroiliitis sum score (SSS, 0-8; left + right mNY grades) over successive clinic visits
Methodological detailslinear mixed-effects models, Cox regression
- Linear mixed-effects models
- Cox regression
Main finding
As reported in the abstract
Progression in SSS by at least one grade
Patients with SSS progression by ≥1 grade
475 of 1056
45%
Observational data: associations, not effects.
Secondary outcomes
Incident definite mNY sacroiliitis (patients without definite mNY sacroiliitis at baseline and ≥1 follow-up radiograph)
- Developed definite mNY sacroiliitis
- 189 (22.7%)
- Univariable Cox: nail disease, higher PASI, abnormal ESR/CRP, higher DAPSA and syndesmophytes associated with progression; b/tsDMARD exposure and later eras with lower progression; effects attenuated after adjustment
- n = 831
Original publication
Radiographic sacroiliitis progression in psoriatic arthritis. Rheumatology (Oxford). Published 1 July 2026. doi:10.
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