Spondyloarthritis & psoriatic arthritis
Psoriatic arthritis phenotype clusters and their association with treatment response: a real-world longitudinal cohort study from the psoriatic arthritis research consortium
Authors' conclusion
Data-driven clusters with distinct therapy responses identified in this real-world study highlight the extensive heterogeneity in PsA and the central role of psoriasis and musculoskeletal severity in treatment outcomes.
Study context
- Population
- Patients with psoriatic arthritis (PsA) in the multicentre PsA Research Consortium (PARC) study, real-world setting339 starting or changing therapy
- Participants
- 627 patients
- Exposure
- Data-driven PsA phenotype clusters compared for response to new immunomodulatory therapy and TNFi
- Outcome
- Phenotype clusters and their trajectories, and association of clusters with treatment response
Methodological detailsmulticentre, real-world, longitudinal, factor analysis of mixed data, hierarchical clustering on principal components
- Multicentre
- Real-world
- Longitudinal
- Factor analysis of mixed data
- Hierarchical clustering on principal components
Main finding
As reported in the abstract
Phenotype clusters (proportion of patients)
Observational data: associations, not effects.
Further findings
Response to new immunomodulatory therapy (cDAPSA, PsAID) among patients starting or changing therapy · mean follow-up of 0.7 years, SD 0.8
- Significant differences in response between clusters, with Cluster 3 showing the largest improvements in cDAPSA and PsAID
- n = 339
Response among those starting TNFi
- No differences between clusters
- n=218
cDAPSA remission and PsAID patient acceptable symptom state
- cDAPSA remission
- 10%
- PsAID patient acceptable symptom state
- 54%
Cluster transitions over time
- Clusters remained stable over time despite treatment changes; some transitions, notably from Cluster 3 to milder clusters
Original publication
Psoriatic arthritis phenotype clusters and their association with treatment response: a real-world longitudinal cohort study from the psoriatic arthritis research consortium. Ann Rheum Dis. Published 2 January 2025. doi:10.
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