Spondyloarthritis & psoriatic arthritis
Understanding the Psoriasis Phenotype Associated With Psoriatic Arthritis Using the PURE-4 Questionnaire: Insights From Spanish Real-World Settings
Authors' conclusion
Greater PsO involvement in neck, knees, hands, and feet as well as in high-impact areas of patients who developed PsA provides additional information on the arthritogenic phenotype of PsO in our study population compared to locations generally linked to arthritis risk, such as the nails or scalp.
Study context
- Population
- Patients with psoriasis who completed the PURE-4 validation study, Spanish real-world settings
- Participants
- 253 patients
- Exposure
- Patients with PsO who developed psoriatic arthritis (PsA) vs PsO only
- PsAn = 46
- Outcome
- Baseline PsO location
- Follow-up
- Baseline
Methodological detailsanalysis of the PURE-4 validation study, real-world settings
- Analysis of the PURE-4 validation study
- Real-world settings
Main finding
As reported in the abstract
- PsA
- neck involvement 13% vs 3.4%; P < 0.01
- PsA
- knee involvement 71.4% vs 50%; P = 0.02
- PsA
- hand involvement 40% vs 17.7%; P < 0.01
- PsA
- feet involvement 22.9% vs 9.8%; P = 0.03
Observational data: associations, not effects.
Further findings
PURE-4 item 4 (peripheral joint pain with swelling), Assessment I
P = 0.03
PURE-4 item 4 (peripheral joint pain with swelling), Assessment II
P < 0.01
| Outcome | PsA | PsO only | P value |
|---|---|---|---|
| PASI · baseline | 8.7 (SD 5.6) | 6.8 (SD 5.0) | P = 0.03 |
| DLQI · baseline | 9.9 (SD 6.9) | 7.6 (SD 6.7) | P = 0.09 |
- PURE-4 item 4 (peripheral joint pain with swelling), Assessment I: most prevalent PURE-4 item among PsA
Original publication
Understanding the Psoriasis Phenotype Associated With Psoriatic Arthritis Using the PURE-4 Questionnaire: Insights From Spanish Real-World Settings. J Rheumatol. Published 1 June 2025. doi:10.
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