Spondyloarthritis & psoriatic arthritis
RANTES is a possible marker of paradoxical psoriatic arthritis
Study context
- Population
- Patients with psoriasis (PsO), with or without concurrent psoriatic arthritis (PsA), who had undergone biologic therapy
- Participants
- 23 patients
- Comparison
- PsO patients who developed paradoxical PsA vs those without paradoxical PsA, after ex vivo exposure to culprit biologics
- Outcome
- Cytokine and chemokine levels after PBMC stimulation and ex vivo treatment with biologics
Methodological detailsex vivo PBMC stimulation with Streptococcus pyogenes, ex vivo treatment with each patient's biologics
- Ex vivo PBMC stimulation with Streptococcus pyogenes
- Ex vivo treatment with each patient's biologics
Main finding
As reported in the abstract
RANTES levels after exposure to culprit biologics
- Significant elevation in RANTES levels in paradoxical psoriatic arthritis (PPsA) vs without PPsA
- Notable decrease in IFN-γ levels
- PPsA vs Without PPsA: P = 0.001
Original publication
RANTES is a possible marker of paradoxical psoriatic arthritis. Clin Exp Rheumatol. Published 7 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →