Spondyloarthritis & psoriatic arthritis
Association between resolution of MRI-detected inflammation and improved clinical outcomes in axial spondyloarthritis under long-term anti-TNF therapy
Authors' conclusion
The presence of inflammation on SI joints-MRI is associated with higher disease activity in axSpA. Resolution of inflammation on MRI is associated with better clinical outcomes in the long-term follow-up.
Study context
- Population
- Patients with active axial spondyloarthritis (axSpA) in the ESTHER trial treated with etanercept for at least 6 monthsof 76 ESTHER patients
- Comparison
- Resolution vs presence of MRI-detected SI joint inflammation (osteitis) under long-term etanercept
Methodological detailspost-hoc analysis, longitudinal analysis, MRIs of spine and SI joints at baseline, week 24, week 48 and yearly thereafter
- Post-hoc analysis
- Longitudinal analysis
- MRIs of spine and SI joints at baseline, week 24, week 48 and yearly thereafter
Primary result
As reported in the abstract
Association of MRI inflammation with ASDAS
- Higher SI joint osteitis score and Axial Spondyloarthritis Disease Activity Score (ASDAS) at same time point (β)
- 0.08 (95% CI 0.05; 0.11)
- Higher SI joint osteitis score and ASDAS 6 months later (β)
- 0.05 (95% CI 0.02; 0.07)
- Resolution of SI joint osteitis (Berlin osteitis score ≤1) and ASDAS at next time point (β)
- −0.26 (95% CI −0.42; −0.09)
- Resolution of SI joint osteitis and ASDAS low disease activity at next time point (OR)
- 5.61 (95% CI 1.06; 29.67)
- Resolution of SI joint osteitis and ASDAS inactive disease at next time point (OR)
- 2.23 (95% CI 1.01; 4.94)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between resolution of MRI-detected inflammation and improved clinical outcomes in axial spondyloarthritis under long-term anti-TNF therapy. RMD Open. Published 6 January 2025. doi:10.
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