Spondyloarthritis & psoriatic arthritis
Ankylosed posterior spinal structures: the catalyst for syndesmophytes growth and impaired spinal mobility in axial spondyloarthritis
Authors' conclusion
Ankylosed posterior spinal structures emerged as the paramount driver of syndesmophytes growth and a critical impediment to spinal mobility in axSpA.
Study context
- Population
- Patients with axSpA with baseline and 2-year thoracic and lumbar spine CT
- Participants
- 94 patients
- Outcome
- Syndesmophytes growth (per vertebral syndesmophytes unit) and risk factors for spinal structural progression
- Follow-up
- 2 years
Methodological details2-year follow-up, CT-based, linear mixed-effects model, generalized linear mixed-effects models
- 2-year follow-up
- CT-based
- Linear mixed-effects model
- Generalized linear mixed-effects models
Main finding
As reported in the abstract
Syndesmophytes growth
- Syndesmophytes growth, proportion of vertebral syndesmophytes unit (VSUs)
- 44.99%
- Baseline facet joints ankylosis/erosion and costovertebral/costotransverse joints ankylosis associated with syndesmophytes growth
- P < 0.05
- Contribution: changes of facet joints
- 56.84%
- Contribution: costotransverse joints
- 17.65%
- Contribution: costovertebral joints
- 16.26%
- Contribution: age
- 6.08%
Observational data: associations, not effects.
Further findings
Facet joint structural progression · 2 years
- Facet joints progressed
- 8.79% (281/3196)
- Of these, progressed to ankylosis
- 43.77%
- Contribution: age
- 6.56%
- Contribution: baseline ankylosis/erosion
- 48.02%
Costovertebral joint progression · 2 years
- Costovertebral joints progressed
- 16.31%
- Predictor: age
- 3.63%
- Predictor: 2-year costotransverse lesions progression
- 12.30%
Costotransverse joint progression · 2 years
- Costotransverse joints progressed
- 2.07%
- Correlate: costovertebral lesions
- 25.61%
- Correlate: age
- 0.81%
Contributors to BASMI change · 2 years
- Ankylosed costovertebral joints
- 25.10%
- Ankylosed facet joints
- 16.86%
- Ankylosed costotransverse joints
- 12.72%
- Syndesmophytes growth
- 4.45%
Original publication
Ankylosed posterior spinal structures: the catalyst for syndesmophytes growth and impaired spinal mobility in axial spondyloarthritis. Rheumatology (Oxford). Published 29 May 2025. doi:10.
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