Spondyloarthritis & psoriatic arthritis
Relationship between spinal lesions related to axial spondyloarthritis and degenerative spinal lesions: 10-year follow-up of the DESIR cohort
Authors' conclusion
Although significant associations were found between axSpA-related lesions and DLs at the same time point, no temporal relationship was observed. On radiographs, syndesmophytes increased the risk of syndesmophytes at adjacent levels, but there was no association with osteophyte development. AxSpA-related lesions and DLs coexist, but progress independently of each other.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from the DESIR cohort; whole spine MRI and cervical/lumbar spine radiographs at baseline/5Y/10Y46% men
- Participants
- 326 patients
- Outcome
- Relationship between spinal axSpA-related lesions and degenerative lesions (DLs)
- Follow-up
- 10 years
Methodological details10-year follow-up, multilevel (patient and vertebra) generalized estimating equation (GEE) models, time-lagged autoregressive GEE models, three independent readers
- 10-year follow-up
- Multilevel (patient and vertebra) GEE models
- Time-lagged autoregressive GEE models
- Three independent readers
Main finding
As reported in the abstract
axSpA-related lesions on MRI vs total degenerative lesions (DLs) on MRI, β-coefficients (significant, small effect sizes)
0.07-0.17
Paravertebral syndesmophytes vs total DLs on radiographs, β-coefficient
0.37
95%CI 0.26–0.48
Observational data: associations, not effects.
Further findings
Risk of adjacent syndesmophyte with syndesmophytes (radiographs)
| OR (95% CI) | ||
|---|---|---|
| Syndesmophytes | 6.92 (2.44–19.61) | |
| 0.050.21520Odds ratio (log scale) |
Risk of adjacent osteophytes with syndesmophytes (radiographs)
| OR (95% CI) | ||
|---|---|---|
| Syndesmophytes | 1.05 (0.25–4.36) | |
| 0.20.5125Odds ratio (log scale) |
- Risk of adjacent syndesmophyte with syndesmophytes (radiographs): time-lagged autoregressive GEE model, after excluding vertebrae with both lesions
- Risk of adjacent osteophytes with syndesmophytes (radiographs): time-lagged autoregressive GEE model, after excluding vertebrae with both lesions
Original publication
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