Spondyloarthritis & psoriatic arthritis
Determining the best discriminatory physical functioning outcome measurement instrument for psoriatic arthritis trials: A meta-epidemiological study
Authors' conclusion
HAQ-DI and SF-36-PF were equally responsive to change and superior to SF36-PCS in PsA RCTs.
Study context
- Population
- Randomised trials in psoriatic arthritis (PsA)42 articles (31 RCTs)
- Comparison
- HAQ-DI vs SF36-PF vs SF36-PCS: discriminant capacity (standardized mean differences (SMDs)) for physical functioning in PsA RCTs
- Outcome
- Discriminant capacity: difference in SMDs between outcome measurement instruments
Methodological detailsnetwork meta-analysis, multiple-treatment meta-analysis
- Network meta-analysis
- Multiple-treatment meta-analysis
Pooled result
As reported in the abstract
Difference in SMDs (network meta-analysis)
Each group vs SF36-PCSDifference in SMDs (95 % CI)
HAQ-DI
0.057(0.003–0.110)
SF36-PF
0.109(0.032–0.185)
Further pooled results
| Outcome | Difference in SMDs (95 % CI) | |
|---|---|---|
| Difference in SMDs, direct comparisonsSF36-PFvs SF36-PCS18 randomized comparisons | 0.101 (0.018–0.184) | |
| −0.100.10.2Difference (linear scale) |
| Outcome | Difference in SMDs (95 % CI) |
|---|---|
| Difference in SMDs, direct comparisonsBetween HAQ-DI and SF36-PF · 18 randomized comparisons | 0.059 (0.142–0.024) |
Original publication
Determining the best discriminatory physical functioning outcome measurement instrument for psoriatic arthritis trials: A meta-epidemiological study. Semin Arthritis Rheum. Published 29 December 2025. doi:10.
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