Spondyloarthritis & psoriatic arthritis
Almost half of the patients with axial spondyloarthritis reporting an acceptable symptom state have high disease activity; data from two standard-of-care cohorts
Authors' conclusion
In daily clinical practice, 3 out of 4 axSpA patients report an acceptable symptom state, although almost half of them have high disease activity. In line, the ASDAS threshold for predicting PASS is 2.6.
Study context
- Population
- Patients with axial spondylarthritis (axSpA) in two Dutch standard-of-care cohorts
- Participants
- 673 vs 159
- Exposure
- GLAS vs SpA-Net
- GLASn = 673
- SpA-Netn = 159
- Outcome
- Proportion of axSpA patients reporting PASS
Methodological detailsexternal validation cohort, multivariable logistic regression
- External validation cohort
- Multivariable logistic regression
Main finding
As reported in the abstract
Proportion reporting PASS (acceptable symptom state)
GLAS patients perceiving their symptom state as acceptable
77 %
Of those in PASS, axSpA Disease Activity Score (ASDAS) ≥2.1
44 %
Observational data: associations, not effects.
Further findings
Determinants of PASS (multivariable regression)
- Lower ASDAS, absence of tender entheses and older age independently associated with PASS (R²)
- 0.39
ASDAS accuracy in predicting PASS
- AUC
- 0.84 (95 % CI 0.80-0.85)
- Optimal ASDAS cut-off
- 2.6
- Sensitivity
- 78 %
- Specificity
- 77 %
External validation in SpA-Net
- Similar results in the 159 SpA-Net patients
Original publication
Almost half of the patients with axial spondyloarthritis reporting an acceptable symptom state have high disease activity; data from two standard-of-care cohorts. Semin Arthritis Rheum. Published 29 December 2025. doi:10.
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