Spondyloarthritis & psoriatic arthritis
Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis
Pooled result · ASAS40 response, all advanced therapiesResult — go to the resultOdds ratio 1.88 95% CI 1.44–2.46Authors' conclusion
Female patients with axSpA are less likely to achieve efficacy outcomes on advanced therapies compared to their male counterparts, with similar differences across medication classes.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs) of advanced therapies (literature search until March 19, 2023)
- Participants
- 23,748 patients79 RCTs
- Comparison
- Male vs female patients with axSpA on advanced therapies
- Outcome
- ASAS40 response, men vs women
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
ASAS40 response, all advanced therapies
Odds ratio
1.88
95% CI 1.44–2.46
Malevs Female
OR 1.88 (95% CI 1.44–2.46)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| ASDAS-LDA/ID, all advanced therapies | 2.19 (1.47–3.26) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR |
|---|---|
| ASAS40 response, by medication classMale vs Female · IL-17Ai | 1.82 |
| ASAS40 response, by medication classMale vs Female · TNFi | 2.42 |
| ASDAS-LDA/ID, by medication classMale vs Female · IL-17Ai | 2.08 |
| ASDAS-LDA/ID, by medication classMale vs Female · TNFi | 2.42 |
ASAS40 response, by medication class
- Male patients had numerically higher values for IL-17A/Fi
Baseline characteristics by sex
- Women significantly older and had higher pain scores; men had higher CRP levels
Reporting by sex
- Trials reporting baseline characteristics by sex
- 9 trials (11.4%)
- Trials reporting efficacy end points by sex
- 22 trials (28%)
- Trials reporting safety end points by sex
- 9 trials (11.4%)
Original publication
Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 19 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →