Spondyloarthritis & psoriatic arthritis
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial
Authors' conclusion
In r-axSpA, vertebral corner inflammation may lead to syndesmophyte formation but in a minority of cases via visible fat deposition.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA), assessed at T0, T1 (SIAS: 1 year; ASSERT: 24 weeks) and T2 (2 years)vertebral corners with baseline fat or syndesmophyte ignored
- Participants
- 49 vs 168
- Comparison
- Vertebral corner inflammation at T0 vs no inflammation, with new fat deposition as mediator
- SIASn = 49
- ASSERTn = 168
- Primary endpoint
- Proportion of the total effect of vertebral corner inflammation on new syndesmophyte formation explained via intermediate new fat deposition
- Follow-up
- T2 (2 years)
Methodological detailsmediation analysis, vertebral corner level analysis
- Mediation analysis
- Vertebral corner level analysis
Primary result
As reported in the abstract
Effect of inflammation (T0) on new syndesmophyte in same vertebral corner (T2): total effect and part via new fat deposition (mediation analysis)
- SIAS: total effect of inflammation on probability of new syndesmophyte
- 9.3%
- SIAS: effect via intermediate new fat deposition
- 0.2%
- SIAS: proportion of total effect via new fat deposition
- 2%
- ASSERT: total effect
- 7.3%
- ASSERT: effect via new fat deposition
- 0.8%
- ASSERT: proportion of total effect via new fat deposition
- 10%
Original publication
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial. RMD Open. Published 5 July 2023. doi:10.
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