Spondyloarthritis & psoriatic arthritis
Sacroiliac damage on MRI in axial spondyloarthritis and chronic back pain, women with postpartum back pain, runners and healthy subjects
Authors' conclusion
Structural changes resembling axSpA may occur in individuals who do not have axSpA, but at a lower rate than inflammatory changes. Erosions and fatty lesions are most specific. Using cut-off definitions for these structural lesions results in good discrimination between axSpA and non-axSpA. In axSpA, structural lesions primarily occur in concordance with ongoing inflammation.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA), chronic back pain, women with postpartum back pain, runners and healthy subjects
- Participants
- 172 patients
- Exposure
- axSpA vs chronic back pain, postpartum back pain, runners and healthy subjects
- axSpAn = 47
- Chronic back painn = 47
- Postpartum back painn = 7
- Runnersn = 24
- Healthyn = 47
- Outcome
- Structural lesions in sacroiliac joints on MRI (erosions, fatty lesions, sclerosis, ankylosis)
Methodological detailstwo trained readers, adjusted SPARCC scoring method
- Two trained readers
- Adjusted SPARCC scoring method
Main finding
As reported in the abstract
axSpA
79%
37 of 47
Observational data: associations, not effects.
Further findings
Erosions on MRI-SI
- Uncommon in chronic back pain, runners and healthy individuals
Fatty lesions on MRI-SI
- Uncommon in chronic back pain, runners and healthy individuals
Erosions, fatty lesions and ankylosis, axSpA vs chronic back pain
- Statistically significant difference in prevalence of erosions, fatty lesions and ankylosis between axSpA and chronic back pain; ankylosis rare in both groups
Cut-off definitions, axSpA vs non-axSpA
- Leiden cut-off definitions more specific than ASAS cut-offs
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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