Spondyloarthritis & psoriatic arthritis
Clinical features, treatment, and outcome of isotretinoin-associated sacroiliitis
Authors' conclusion
The cessation of isotretinoin therapy, coupled with the administration of NSAIDs, can effectively alleviate the symptoms experienced by patients.
Study context
- Population
- Patients with isotretinoin-associated sacroiliitis from published clinical reports (median age 21 years; 83.6% from Turkey)
- Participants
- 67 patients
- Outcome
- Clinical characteristics of isotretinoin-associated sacroiliitis
Methodological detailsliterature database search up to March 31, 2025
- Literature database search up to March 31, 2025
Main finding
As reported in the abstract
- Median age, years (range 14, 44)
- 21
- Patients from Turkey
- 56 (83.6%)
- Median time to sacroiliitis after isotretinoin administration, months (range 0.4, 24)
- 2.5
- Low back pain
- 70.1%
- Hip pain
- 44.8%
- Magnetic resonance imaging (MRI) showing sacroiliitis
- 73.1%
- MRI showing bone marrow edema
- 34.3%
Observational data: associations, not effects.
Original publication
Clinical features, treatment, and outcome of isotretinoin-associated sacroiliitis. Arthritis Res Ther. Published 26 May 2025. doi:10.
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