Spondyloarthritis & psoriatic arthritis
Biomarkers reflecting disturbed gut barrier under treatment with TNF inhibitors in radiographic axial spondyloarthritis
Authors' conclusion
Serum levels of LBP and calprotectin are associated with disease activity in patients with r-axSpA and decrease with TNFi response. In contrast, serum zonulin levels showed no association with disease activity or treatment response, arguing against a strict correlation between intestinal permeability and disease activity in axSpA.
Study context
- Population
- Patients with active radiographic axial spondyloarthritis (r-axSpA) of the German Spondyloarthritis Inception Cohort starting tumour necrosis factor inhibitor (TNFi), and controls with chronic back pain
- Participants
- 121 vs 63
- Exposure
- r-axSpA patients starting TNFi vs controls with chronic back pain
- r-axSpAn = 121
- Controlsn = 63reference
- Outcome
- Serum LBP, zonulin and calprotectin levels and their association with disease activity and treatment response
- Follow-up
- Baseline and after 1 year of TNFi therapy
Methodological detailslongitudinal, regression analysis, German Spondyloarthritis Inception Cohort
- Longitudinal
- Regression analysis
- German Spondyloarthritis Inception Cohort
Main finding
As reported in the abstract
- Lipopolysaccharid-binding protein (LBP) association with ASDAS, longitudinal (ß)
- 0.08 (95% CI 0.06 to 0.10)
- LBP association with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), longitudinal (ß)
- 0.08 (95% CI 0.04 to 0.12)
- LBP association with C reactive protein (CRP), longitudinal (ß)
- 1.69 (95% CI 1.04 to 2.34)
- Calprotectin association with ASDAS (ß)
- 0.04 (95% CI 0.01 to 0.07)
- Calprotectin association with CRP (ß)
- 0.82 (95% CI 0.27 to 1.37)
Observational data: associations, not effects.
Original publication
Biomarkers reflecting disturbed gut barrier under treatment with TNF inhibitors in radiographic axial spondyloarthritis. RMD Open. Published 31 December 2024. doi:10.
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