Spondyloarthritis & psoriatic arthritis
Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease
Authors' conclusion
Our work supports the existence of a common gut dysbiosis in SpA and related inflammatory pathologies.
Study context
- Population
- Patients in the German Spondyloarthritis Inception Cohort naive to or without bDMARD treatment for >3 months before enrollment, and back pain controls277 patients and 62 controls
- Participants
- 72 / 103 / 102 / 62
- Exposure
- Patients with Crohn's disease (CD), acute anterior uveitis (AAU) and spondyloarthritis (SpA) vs back pain controls without inflammatory disorder
- CDn = 72
- AAUn = 103
- SpAn = 102
- Controlsn = 62reference
- Outcome
- Gut microbiota composition
Methodological details16S ribosomal RNA sequencing of stool samples, discriminatory statistical methods, German Spondyloarthritis Inception Cohort
- 16S ribosomal RNA sequencing of stool samples
- Discriminatory statistical methods
- German Spondyloarthritis Inception Cohort
Main finding
As reported in the abstract
- Shared immune-mediated disease signal: low abundances of Lachnospiraceae taxa vs controls, most notably Fusicatenibacter
- Fusicatenibacter most abundant in controls receiving NSAID monotherapy; implied to partially mediate higher serum CRP
- SpA: enrichment of Collinsella
- HLA-B27+ individuals: enriched Faecalibacterium
- CD: higher abundances of a Ruminococcus taxon
- Previous conventional/synthetic DMARD therapy associated with increased Akkermansia
Observational data: associations, not effects.
Original publication
Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease. Arthritis Rheumatol. Published 19 October 2023. doi:10.
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