Spondyloarthritis & psoriatic arthritis
Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case–control and sibling study
Authors' conclusion
Having older siblings and a history of tonsillectomy in childhood were independently associated with development of AS, even after adjustment for family-shared factors in a sibling comparison analysis.
Study context
- Population
- Swedish nationwide register: Ankylosing spondylitis (AS) cases and matched general-population controls; sibling comparison of patients with AS and siblings without SpAsibling analysis: 3965 AS, 6070 siblings
- Participants
- 5,612 vs 22,042
- Comparison
- AS cases vs matched individuals without inflammatory arthritis; perinatal factors and childhood infections
- AS casesn = 5,612
- Controlsn = 22,042reference
- Outcome
- Perinatal and early-life risk factors (childhood infections, perinatal factors incl. fetal growth) for AS
Methodological detailsnationwide, register-based, matched, conditional logistic regression
- Nationwide
- Register-based
- Matched
- Conditional logistic regression
Main finding
As reported in the abstract
Odds of AS by early-life factor
Adjusted odds ratio (95% CI)
One older siblingvs No older sibling
1.12(1.04–1.22)
Childhood tonsillectomy
1.30(1.13–1.49)
Observational data: associations, not effects.
Original publication
Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case–control and sibling study. RMD Open. Published 16 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →