Spondyloarthritis & psoriatic arthritis
Proposal for a disease severity score for axial spondyloarthritis: results from an Italian longitudinal study
Authors' conclusion
Despite its limitations, including single-centre design and absence of formal validation, the SpA-SI demonstrated strong correlations with established indices and sensitivity to change.
Study context
- Population
- bDMARD-naive patients with axial spondyloarthritis (axSpA), Italy
- Participants
- 100 patients
- Exposure
- Spondyloarthritis Severity Index (SpA-SI) at baseline vs 6 months; correlation with ASDAS and BASDAI
- Outcome
- SpA-SI score (range 0 to ≥7)
Methodological detailslongitudinal, single-centre
- Longitudinal
- Single-centre
Main finding
As reported in the abstract
| Group | Value | Range |
|---|---|---|
| Baseline | median 7.2 (IQR 6.2–7.6) | 3.4-12.2 |
| 6 months | median 4.9 (IQR 2.8–7.0) | 1.2-9.5 |
Value
Baselinemedian 7.2 (IQR 6.2–7.6)
6 monthsmedian 4.9 (IQR 2.8–7.0)
Range
Baseline3.4-12.2
6 months1.2-9.5
- 6 months vs Baseline: P < 0.001 — significantly improved
Observational data: associations, not effects.
Further findings
Correlation of SpA-SI with ASDAS
- Strong correlation with ASDAS, continuous and in categorised disease activity groups (p<0.001)
Correlation of SpA-SI with BASDAI
- Baseline: r (p<0.001)
- 0.47
- 6 months: r (p<0.001)
- 0.79
- Similar significance when analysed by group
Original publication
Proposal for a disease severity score for axial spondyloarthritis: results from an Italian longitudinal study. Clin Exp Rheumatol. Published 31 January 2025. doi:10.
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