Spondyloarthritis & psoriatic arthritis
Disease characteristics, co-morbidities and treatment response in a contemporary axial spondyloarthritis cohort: Analysis of 717 patients from the Greek axial spondyloarthritis (AxSpA) registry
Authors' conclusion
In this sizable contemporary AxSpA cohort, one third of patients still miss treatment targets. Additional to cardiovascular risk factors, depression and osteoporosis are considerably prevalent. Smoking predicts a higher ASDAS, while HLA B27 positivity predicts syndesmophyte formation, but also better ASDAS responses.
Study context
- Population
- Patients with axSpA in the Greek AxSpA registry (64.9% males; mean age 50 years; median disease duration 13 years)Greek AxSpA registry
- Participants
- 717 patients
- Outcome
- Baseline disease characteristics, comorbidities and treatment
- Follow-up
- Baseline
Methodological detailsmulticentre, observational, registry
- Multicentre
- Observational
- Registry
Main finding
As reported in the abstract
- r-axSpA
- Two thirds
- Peripheral arthritis ever (equal to enthesitis)
- 45%
- Hip involvement
- 28%
- Increased BMI
- 60%
- Dyslipidemia
- 30%
- Hypertension
- 30%
- Depression
- 14%
- Osteoporosis
- 10%
- Receiving a bDMARD
- 78%
- No treatment
- 12%
- Inactive disease or low disease activity
- 65%
Observational data: associations, not effects.
Further findings
Disease activity, r-axSpA vs nr-axSpA
- ASDAS, BASDAI and BASFI comparable between r-axSpA and nr-axSpA
- nr-axSpA patients reported higher Global and Pain VAS scores
Predictors of ASDAS (multivariable)
- Higher ASDAS: dactylitis ever, current smoking, number of previous bDMARDs
- Lower ASDAS: HLA-B27 positivity, low alcohol intake
Predictors of syndesmophytes (multivariable)
- Male sex, HLA-B27 positivity, high CRP at diagnosis, older age and longer diagnosis delay independently predicted syndesmophytes
Original publication
Disease characteristics, co-morbidities and treatment response in a contemporary axial spondyloarthritis cohort: Analysis of 717 patients from the Greek AxSpA registry. Semin Arthritis Rheum. Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →