Spondyloarthritis & psoriatic arthritis
The Sensitivity to Change of the ASAS Health Index in an Observational Real-Life Cohort Study
Authors' conclusion
As expected, ASDAS and BASDAI as disease activity scores showed high sensitivity to change, whereas changes in physical function (BASFI), mental health (WHO-5), and the broader concept of functioning and health (ASAS HI) were moderate.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from the RABBIT-SpA register with ≥12 months follow-up and available ASAS HI questionnaires
- Participants
- 667 patients
- Exposure
- Sensitivity to change of ASAS HI vs BASDAI, ASDAS, BASFI and WHO-5
- bDMARDn = 552
- Controln = 115reference
- Outcome
- Sensitivity to change (SRM) of ASAS HI vs established measures of disease activity, function and mental health
- Follow-up
- Month 12
Methodological detailsdisease register (RABBIT-SpA), real-life
- Disease register (RABBIT-SpA)
- Real-life
Main finding
As reported in the abstract
SRM, baseline to month 12
| Group | SRM ASAS HI | SRM BASFI | SRM WHO-5 | SRM BASDAI | SRM ASDAS |
|---|---|---|---|---|---|
| bDMARD | 0.52 | 0.59 | 0.65 | 0.73 | 0.90 |
bDMARD
SRM ASAS HI0.52
SRM BASFI0.59
SRM WHO-50.65
SRM BASDAI0.73
SRM ASDAS0.90
Observational data: associations, not effects.
Further findings
| Outcome | bDMARD | Control |
|---|---|---|
| Mean ASAS HI, baseline to month 12 | 5.1 | 5.6 |
| Baseline mean | 6.9 | 5.9 |
Most frequently affected ASAS HI domains
- Pain
- 78%
- Maintaining body position
- 75%
- Energy/drive
- 73%
ASAS HI items
- bDMARD: improvement in all items
- Control: largest improvement in pain
Original publication
The Sensitivity to Change of the ASAS Health Index in an Observational Real-Life Cohort Study. J Rheumatol. Published 1 August 2022. doi:10.
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