Profile of HLA-B27-positive enthesitis/spondylitis-related arthritis in Senegal, West Africa
Authors' conclusion
In our study, HLA-B27-positive ERA was found in our Senegalese cohort mainly in adolescents of the Fula ethnic group. 22 (70.9%) patients developed ankylosing spondylitis at adulthood. The disease was very active at the time of diagnosis with significant functional disability.
Study context
- Population
- Patients with HLA-B27-positive enthesitis/spondylitis-related arthritis (ERA) (juvenile idiopathic arthritis (JIA)), symptom onset <18 years, 2019 PRINTO provisional criteria, Senegal, January 2012 to December 202220 males
- Participants
- 31 patients
- Outcome
- Clinical features, disease activity (Ankylosing Spondylitis Disease Activity Score (ASDAS), BASDAI), functional disability (BASFI) and treatment at diagnosis
- Follow-up
- Diagnosis
Methodological detailsmedical records review
- Medical records review
Main finding
As reported in the abstract
Features at diagnosis
- Males
- 20 of 31 (64.5%)
- Fula ethnicity
- 27 (87%)
- Median age at symptom onset
- 12 years
- Median age at diagnosis
- 19 years
- Family history of SpA
- 7
- Peripheral arthritis
- 29 (93.5%)
- Peripheral arthritis in lower limbs
- 27/29 (93.1%)
- Heel enthesitis
- 26 (83.8%)
- Axial involvement
- 27 (87%)
- Low back pain
- 24 (88.8%)
- Sacroiliac/buttock pain
- 22 (81.5%)
- Anterior uveitis
- 7 (22.5%)
- Elevated ESR
- 65.5%
- Elevated CRP
- 57.1%
- Sacroiliitis on imaging
- 22
- Mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)
- 5.5/10
- High active disease (BASDAI ≥ 4/10)
- 77.2%
- Mean ASDAS-ESR/CRP
- 3.8
- Mean Bath Ankylosing Spondylitis Functional Index (BASFI)
- 5.4/10
- High functional disability (BASFI ≥ 4/10)
- 80%
- Treated with MTX and NSAIDs
- 27 (87%)
Observational data: associations, not effects.
Further findings
Disease activity and function after treatment · 6 months
- Mean BASDAI
- 3/10
- Mean BASFI
- 2.5/10
Developed AS at adulthood
- Patients developing AS
- 22 (70.9%)
Original publication
Profile of HLA-B27-positive enthesitis/spondylitis-related arthritis in Senegal, West Africa. Pediatr Rheumatol Online J. Published 29 February 2024. doi:10.
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