Childhood-onset rheumatoid arthritis at a tertiary hospital in Senegal, West Africa
Authors' conclusion
In our study, CORA mainly affects 13-year-old girls, characterised by high disease activity with joint deformity and significant functional impairment. Treatment is mainly based on methotrexate, prednisone and hydroxychloroquine.
Study context
- Population
- Patients with childhood-onset rheumatoid arthritis (CORA) (symptom onset <18 years, 2019 PRINTO provisional criteria for rheumatoid factor (RF)-positive JIA), rheumatology department of Aristide Le Dantec Hospital, Dakar, Senegal, January 2020 to December 202218 (85.7%) female
- Participants
- 21 patients
- Outcome
- Clinical features, disease activity, functional disability and treatment of CORA at diagnosis
- Follow-up
- At diagnosis
Methodological detailsmixed cohort, medical record review, single-centre
- Mixed cohort
- Medical record review
- Single-centre
Main finding
As reported in the abstract
- Age at symptom onset, mean ± SD (years)
- 13.0 ± 3.0
- Age at diagnosis, mean ± SD (years)
- 16.4 ± 4.2
- Morning stiffness, patients
- 20
- Joint swelling, patients
- 18
- Joint deformities, patients
- 13
- Family history of RA, patients
- 4
- Extra-articular involvement (e.g. rheumatoid nodules), patients
- 5
- ILD, patients
- 2
- Biological inflammatory syndrome
- 90%
- Positive RF
- 16 of 21 (76.2%)
- Positive anti-CCP
- 18 of 20 (90%)
- Positive ANA
- 7 of 12 (58.3%)
- DAS28-ESR, mean
- 5.7 ± 1.0
- High disease activity (DAS28-ESR > 5.1)
- 15 (71.4%)
- DAS28-CRP, mean
- 5.4 ± 1.1
- Health Assessment Questionnaire (HAQ), median
- 2.12
- HAQ, mean
- 1.9
- Treated with MTX
- 19 (90.5%)
- MTX + HCQ combination
- 17 (81%)
- Oral prednisone
- 17 (81%)
- NSAIDs
- 4 (19%)
Observational data: associations, not effects.
Further findings
DAS28-CRP, mean · after 6 months of treatment
- Mean DAS28-CRP
- 2.9
Original publication
Childhood-onset rheumatoid arthritis at a tertiary hospital in Senegal, West Africa. Pediatr Rheumatol Online J. Published 12 September 2023. doi:10.
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