Extra-osseous manifestations in chronic recurrent multifocal osteomyelitis: a retrospective study
Authors' conclusion
The analysis of EO manifestations in CRMO delineates two groups of patients in terms of severity and treatments used.
Study context
- Population
- Chronic recurrent multifocal osteomyelitis (CRMO) patients followed in paediatric rheumatology departments in France, 2015–202287 (65.4%) girls
- Participants
- 133 patients
- Exposure
- CRMO with vs without extra-osseous manifestations
- Extra-osseous (EO)+n = 90
- Outcome
- Frequency, characteristics and treatment of EO events in CRMO
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
EO manifestations (frequency and type)
- Any EO manifestation
- 90 (67.7%)
- Skin lesions
- 51/90 (56.7%)
- Sacroiliitis
- 38/90 (42.2%)
- Enthesitis
- 21/90 (23.3%)
- Arthritis
- 14/90 (15.6%)
- Gastrointestinal manifestations
- 6/90 (6.7%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Treatment by EO statusBiologics taken more frequently by EO+ | P < 0.001 |
- On treatment at last visit — Active disease at last visit · more EO+ than EO- on treatment
- 58 (64.4%) · P = 0.009
Treatment by EO status
- NSAID and bisphosphonate use did not differ by presence or not of EO manifestations
TNFi use and complete remission of osseous and EO manifestations under TNFi
- TNFi used in EO+ patients
- 33 (36.7%)
- Complete remission under TNFi
- 18 (54.5%)
Original publication
Extra-osseous manifestations in chronic recurrent multifocal osteomyelitis: a retrospective study. Rheumatology (Oxford). Published 12 September 2023. doi:10.
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