Disease evolution in systemic juvenile idiopathic arthritis: an international, observational cohort study through Juvenile Inflammatory Rheumatism cohort (JIRcohort)
Authors' conclusion
Our results suggest that the earlier disease onset, the persistence of arthritis throughout the first year of disease evolution and the need of sDMARD might predict a persistent disease course.
Study context
- Population
- Children with sJIA in JIRcohort, 4 countries (3 European, 1 North Africa), 2005–201965 with complete 24-month follow-up
- Participants
- 201 children
- Exposure
- Persistent vs monophasic/polyphasic disease course in sJIA
- Monophasicn = 23
- Polyphasicn = 6
- Persistentn = 36
- Outcome
- Predictors of disease evolution (persistent disease course)
- Follow-up
- 24 months after first diagnosis
Methodological detailsinternational, retrospectively and prospectively collected routine care data
- International
- Retrospectively and prospectively collected routine care data
Main finding
As reported in the abstract
Predictors of persistent disease course
Odds ratio (95% CI)
Disease onset before age 6
2.57(0.70–9.46)
Persistence of arthritis at 12 months post-diagnosis
4.45(0.58–34.20)
Higher use of sDMARD
5.28(1.39–20.01)
Observational data: associations, not effects.
Original publication
Disease evolution in systemic juvenile idiopathic arthritis: an international, observational cohort study through JIRcohort. Pediatr Rheumatol Online J. Published 7 September 2023. doi:10.
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