Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study
Study context
- Population
- Patients with childhood-onset systemic lupus erythematosus (SLE) and gastrointestinal system involvement from 16 paediatric rheumatology referral departments
- Participants
- 123 patients16 centres
- Outcome
- GI manifestations in childhood-onset SLE
Methodological detailsmulticentre, 16 paediatric rheumatology referral departments
- Multicentre
- 16 paediatric rheumatology referral departments
Main finding
As reported in the abstract
GIS involvement: timing and presentation
- Gastrointestinal system (GIS) involvement at initial SLE diagnosis
- 78 (63.4%)
- Gastrointestinal (GI) symptoms developed after SLE diagnosis
- 45 (36.6%)
- Median time to GI symptoms after diagnosis, months (range)
- 12 (3-140)
- Symptoms related to the GI tract (rest diagnosed by laboratory assessments)
- 82 (66.7%)
- Initial symptom: abdominal pain (predominant)
- 77 (62.6%)
- Initial: elevated hepatic transaminases
- 70 (56.9%)
- Initial: hepatomegaly
- 40 (32.5%)
- Initial: diarrhoea
- 26 (21.1%)
- Initial: jaundice
- 11 (8.9%)
- GIS involvement associated with SLE
- 82 (78.6%)
- GIS involvement from comorbidities
- 6 (0.5%)
Observational data: associations, not effects.
Safety
- GIS involvement resulting from drug-related adverse events, patients
- 35 (28.5%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study. Lupus. Published 26 August 2024. doi:10.
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