A simple, clinically usable whole-body MRI system of joint assessment in adolescents and young people with juvenile idiopathic arthritis
Authors' conclusion
The intra- and inter-reader agreements of this WBMRI assessment system are adequate for assessing objective joint inflammation and damage in JIA.
Study context
- Population
- Adolescents and young people with juvenile idiopathic arthritis (JIA) and controls with non-inflammatory musculoskeletal pain undergoing post-contrast Dixon whole-body MRI (WBMRI)3 readers
- Participants
- 60 adolescents
- Exposure
- JIA vs Controls
- JIAn = 47
- Controlsn = 13reference
- Outcome
- Intra- and inter-reader overall agreement (OA) and Gwet's agreement coefficient 2 (GAC2) for detecting participants with ≥1 joint with inflammation or structural damage and joint inflammation or damage at each joint
Methodological detailsprospective, readers blinded to diagnosis
- Prospective
- Readers blinded to diagnosis
Main finding
As reported in the abstract
Agreement of WBMRI joint assessment system
- Inter-reader overall agreement (OA), patients with ≥1 joint with inflammation (grade 2 synovitis)
- 80%
- Inter-reader OA, patients with ≥1 joint with structural damage
- 73%
- Intra-reader OA (readers 1-3), ≥1 joint with inflammation
- 80-90%
- Intra-reader OA (readers 1-3), ≥1 joint with structural damage
- 75-90%
- Inter-reader OA and GAC2 for joint inflammation (G2) at each joint, all joints
- ≥85%
Observational data: associations, not effects.
Original publication
A simple, clinically usable whole-body MRI system of joint assessment in adolescents and young people with juvenile idiopathic arthritis. Rheumatology (Oxford). Published 29 February 2024. doi:10.
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