Detection of inflammation by whole-body MRI in young people with juvenile idiopathic arthritis
Main finding · WBMRI-detected joint inflammationResult — go to the resultDifference 44% 95% CI 20%–68%Authors' conclusion
WBMRI's validity in joint assessment was demonstrated by the higher frequency of inflammation in JIA patients vs controls, and in active vs inactive JIA patients. WBMRI found unsuspected joint inflammation in 49% YP with JIA
Study context
- Population
- Young people (YP) aged 14–24 years with JIA or arthralgia without JIA, one centre
- Participants
- 47 / 25 / 22 / 13
- Exposure
- JIA vs controls with arthralgia without JIA
- JIAn = 47
- Active JIAn = 25
- Inactive JIAn = 22
- Controlsn = 13reference
- Outcome
- Joint inflammation (one or more inflamed joint) detected by WBMRI
Methodological detailssingle-centre, consensus of at least two of three independent radiologists
- Single-centre
- Consensus of at least two of three independent radiologists
Main finding
WBMRI-detected joint inflammation
Difference
44%
95% CI 20%–68%
Events by group
JIAvs Controls
difference 44% (95% CI 20%–68%)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | JIA | Active JIA | Inactive JIA | Difference (95% CI) | |
|---|---|---|---|---|---|
| WBMRI-detected inflammation, activevs inactive JIA | — not stated in the abstract | 76% | 41% | 35% (9%–62%) | |
| −50050100Difference (linear scale) |
— not stated in the abstract
| Outcome | JIA | Active JIA | Inactive JIA |
|---|---|---|---|
| Inflammation in one or more clinically inactive joint | 49% | 14 events | 9 events |
Whole-body MRI (WBMRI)-detected inflammation, active vs inactive JIA
- Associated with a specific biomarker signature
Original publication
Detection of inflammation by whole-body MRI in young people with juvenile idiopathic arthritis. Rheumatology (Oxford). Published 20 January 2024. doi:10.
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