Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients
Authors' conclusion
Peripheral apoptotic lymphocytes could contribute to the prognosis of jSLE and could be used as a predictor for disease activity in jSLE patients.
Study context
- Population
- Juvenile-onset SLE patients and healthy controls
- Participants
- 100 vs 50
- Comparison
- Juvenile-onset SLE patients vs healthy controls
- jSLEn = 100
- Healthy controlsn = 50reference
- Outcome
- Percentages of PB lymphocyte apoptosis (flow cytometry)
Main finding
As reported in the abstract
PB lymphocyte apoptosis percentages
- Significantly higher in jSLE than in healthy controls
- Significantly positively associated with disease activity (SLEDAI-2K)
Observational data: associations, not effects.
Further findings
Plasma cytokines (IL-17, IFN-γ, TNF-α)
- Significantly elevated in jSLE vs healthy controls
- Weak significant positive correlations of peripheral blood (PB) lymphocyte apoptosis with IL-17 and IFN-γ in jSLE
PB lymphocyte apoptosis by clinical and laboratory features in jSLE
- Higher in the presence of some clinical and laboratory features than in their absence
Original publication
Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients. Pediatr Rheumatol Online J. Published 19 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →