Prevalence of STAT3 mutations in patients with rheumatoid arthritis-associated T-cell large granular lymphocytic leukaemia and Felty syndrome
Authors' conclusion
The results suggest that STAT3 mutations are significantly less common in FS than in RA-associated T-LGL leukaemia.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and unexplained neutropenia
- Participants
- 100 patients
- Exposure
- RA-associated T-LGL leukaemia vs Felty syndrome
- RA-associated T-LGL leukaemian = 69
- Felty syndrome (FS)n = 31reference
- Outcome
- Prevalence of STAT3 mutations
Methodological detailsNext-generation sequencing (NGS) of STAT3, T-cell receptor (TCR) rearrangement by BIOMED-2 protocol
- NGS of STAT3
- TCR rearrangement by BIOMED-2 protocol
Main finding
As reported in the abstract
STAT3 mutations
P = 4.7×10-8
Observational data: associations, not effects.
Further findings
Events
| Outcome | RA-associated T-LGL leukaemia | FS |
|---|---|---|
| Samples with STAT3 mutations in the absence of clonal TCR rearrangementCounts are samples | 3 | 5 |
Original publication
Prevalence of STAT3 mutations in patients with rheumatoid arthritis-associated T-cell large granular lymphocytic leukaemia and Felty syndrome. Clin Exp Rheumatol. Published 19 January 2023. doi:10.
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