Cytokines, chemokines and antibodies against histone-3/4 citrullinated peptides in rheumatoid arthritis patients with pulmonary fibrosis
Main finding · Antibodies and cytokines/chemokines at diagnosis and subsequent PFResult — go to the resultOdds ratio 2.26Authors' conclusion
Antibodies against CitH3 peptides and several of the analysed cytokines/chemokines in samples collected at diagnosis were associated with subsequent delevopment of PF in patients with RA.
Study context
- Population
- Inception cohort of 1118 early rheumatoid arthritis (RA) patients; plasma samples collected at RA diagnosisinception cohort of 1118
- Participants
- 60 / 124 / 94
- Comparison
- Early RA with pulmonary fibrosis (PF) vs early RA without PF and matched population controls
- PFn = 60
- Without PFn = 124reference
- Population controlsn = 94
- Outcome
- Antibodies against CitH3/H4 citrullinated peptides and cytokine/chemokine levels at RA diagnosis in relation to subsequent PF
Methodological detailsmatched population controls, Bonferroni corrections
- Matched population controls
- Bonferroni corrections
Main finding
As reported in the abstract
Antibodies and cytokines/chemokines at diagnosis and subsequent PF
Odds ratio
2.26
Observational data: associations, not effects.
Further findings
Correlation of cytokines/chemokines with histone antibodies
- Several cytokines/chemokines correlated significantly with histone antibodies in patients without PF
Partial least squares discriminant analysis in non-smokers
- Antibodies against citrullinated histone peptides and cytokines/chemokines identified significantly in PF in non-smokers
Original publication
Cytokines, chemokines and antibodies against histone-3/4 citrullinated peptides in rheumatoid arthritis patients with pulmonary fibrosis. Arthritis Res Ther. Published 30 July 2025. doi:10.
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