Clonal haematopoiesis and risk of incident rheumatoid arthritis: results from the UK biobank
Authors' conclusion
Common CHIP mutations, including TET2, TP53, and SF3B1 mutations, were not associated with risk of incident RA when restricted to those with most complete general outpatient and hospital record follow-up in the UK Biobank.
Study context
- Population
- Unrelated UK Biobank individuals with genome-wide genotyping, whole exome sequencing (WES) read for CHIP and linked general practice (GP) data, excluding prevalent RA or RA medications at baseline594 incident RA cases
- Participants
- 186,577 individuals
- Exposure
- CHIP mutations vs no CHIP mutation
- Incident RAn = 594
- Outcome
- Incident RA, identified by billing code algorithms
Methodological detailsUK Biobank, Cox regression
- UK Biobank
- Cox regression
Main finding
As reported in the abstract
Any CHIP mutation at >2% VAF at baseline
Observational data: associations, not effects.
Further findings
- Median follow-up, years (IQR 6.4-8.0)
- 7.1
- Median time to RA, years (IQR 2.0-5.6)
- 3.9
Original publication
Clonal haematopoiesis and risk of incident rheumatoid arthritis: results from the UK biobank. Clin Exp Rheumatol. Published 21 September 2025. doi:10.
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