Systemic sclerosis & Raynaud's
Overexpression of BAG3 (Bcl2-associated athanogene 3) in serum and skin of patients with systemic sclerosis
Authors' conclusion
BAG3 is overexpressed in dcSSc patients and may contribute to skin and organ fibrosis by prompting the transition of fibroblasts into myofibroblasts and increasing their survival.
Study context
- Population
- Patients with systemic sclerosis (SSc) and age- and sex-matched healthy controls
- Participants
- 106 SSc patients
- Exposure
- BAG3 serum levels in SSc vs healthy controls
- Limited (lc)n = 47
- dcSScn = 59
- Outcome
- BAG3 serum levels
Methodological detailsage- and sex-matched healthy controls
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
BAG3 serum levels by nailfold video-capillaroscopic (NVC) pattern and interstitial lung disease (ILD)
- Significantly higher in patients with late NVC pattern and ILD
Correlation of BAG3 with disease activity and modified Rodnan skin score (mRSS)
- No correlation with disease activity and mRSS
BAG3 expression in skin biopsies (8 dcSSc patients)
- BAG3 strongly expressed in skin biopsies of dcSSc patients
Original publication
Overexpression of BAG3 (Bcl2-associated athanogene 3) in serum and skin of patients with systemic sclerosis. Clin Exp Rheumatol. Published 5 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →