Systemic sclerosis & Raynaud's
Inflammatory Arthritis in Systemic Sclerosis: Its Epidemiology, Associations, and Morbidity
Authors' conclusion
IA is a common disease manifestation that is more frquently seen in diffuse disease. IA is associated with poor HRQoL and physical disability.
Study context
- Population
- Patients with systemic sclerosis (SSc) prospectively enrolled in the Australian Scleroderma Cohort Study
- Exposure
- SSc with IA vs SSc without IA
- Outcome
- Epidemiology, associations and impact of IA in SSc
Methodological detailslogistic regression
- Logistic regression
Main finding
As reported in the abstract
Prevalence of IA · median follow-up of 4.3 (1.7-8.4) years
IA
33.3%
Observational data: associations, not effects.
Further findings
Associations of IA with SSc manifestations
| OR (95% CI) | P value | ||
|---|---|---|---|
| Diffuse SSc | 1.33 (1.01–1.74) | P = 0.042 | |
| Concurrent musculoskeletal manifestations (joint contractures and tendon friction rubs) | 1.70 (1.34–2.15) | P < 0.001 | |
| Myositis | 2.11 (1.39–3.20) | P < 0.001 | |
| Sicca symptoms | 1.57 (1.14–2.16) | P = 0.006 | |
| PAHNegative association | 0.52 (0.35–0.78) | P = 0.002 | |
| 0.20.5125Odds ratio (log scale) |
Serological associations of IA
| OR (95% CI) | P value | ||
|---|---|---|---|
| RF | 1.13 (0.88–1.44) | P = 0.331 | |
| U1 small nuclear RNP | 1.46 (0.89–2.39) | P = 0.129 | |
| 0.512Odds ratio (log scale) |
Positive anti-CCP antibodies
P < 0.001
- Health-related quality of life (HRQoL) and physical disability · significantly lower HRQoL with IA
- P < 0.001
- HRQoL and physical disability · more physical disability with IA
- P < 0.001
Original publication
Inflammatory Arthritis in Systemic Sclerosis: Its Epidemiology, Associations, and Morbidity. Arthritis Care Res (Hoboken). Published 4 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →