Systemic sclerosis & Raynaud's
Osteolysis in Systemic Sclerosis: A Scoping Review
Authors' conclusion
Despite the effect that osteolysis has on patients with SSc, there is a significant lack of studies on this area.
Study context
- Population
- Studies of osteolysis in systemic sclerosis (SSc)29 articles included
Methodological detailsPRISMA-ScR
- PRISMA-ScR
Main finding
As reported in the abstract
- Included publications heterogeneous in population and inclusion criteria; no standardised method of osteolysis detection
- Most frequently analysed and prevalent location: acro-osteolysis (AO)
- Diffuse cutaneous subtype and anti-topoisomerase I antibody correlated positively with AO
- Disease duration, calcinosis and digital ischaemia most frequently associated with AO; only calcinosis and digital ischaemia predicted AO
- US showed high sensitivity for detection of AO
- No study addressed treatment
Original publication
Osteolysis in Systemic Sclerosis: A Scoping Review. J Rheumatol. Published 1 February 2023. doi:10.
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