Systemic sclerosis & Raynaud's
Epidemiology and Survival of Systemic Sclerosis–Sarcoidosis Overlap Syndrome
Authors' conclusion
Sarcoidosis in SSc is rare but appears to occur more frequently than in the general population. It is associated with pulmonary, lymph node, cutaneous, joint, and hepatic involvement. Stroke occurs more frequently in patients with SSc-sarcoidosis but with no differences in survival.
Study context
- Population
- Patients fulfilling the ACR/EULAR classification criteria for systemic sclerosis (SSc), with and without sarcoidosis
- Participants
- 1,977 patients
- Exposure
- SSc with sarcoidosis vs SSc without sarcoidosis
- SSc-sarcoidosisn = 6
- SScn = 1,971reference
- Outcome
- Time from diagnosis to all-cause mortality
Methodological detailsKaplan-Meier survival analysis
- Kaplan-Meier survival analysis
Main finding
As reported in the abstract
Median survival
P = 0.55
Observational data: associations, not effects.
Further findings
Age at SSc onset
ILD
Pulmonary hypertension
Abnormal nailfold capillaries
Digital ulcers
| Outcome | RR (95% CI) | |
|---|---|---|
| Stroke | 8.59 (1.02–72.00) | |
| 0.050.21520Relative risk (log scale) |
| Outcome | SSc-sarcoidosis | SSc |
|---|---|---|
| Sarcoidosis preceding SSc | 66.66% | — not stated in the abstract |
| Sarcoidosis manifestations | ||
| Pulmonary | 66.66% | — not stated in the abstract |
| Lymphadenopathy | 66.66% | — not stated in the abstract |
| Arthritis | 50% | — not stated in the abstract |
| Cutaneous | 33.33% | — not stated in the abstract |
| Hepatic | 16.66% | — not stated in the abstract |
| Female to male sex ratio | 5:1 | 4.5:1 |
— not stated in the abstract
Prevalence of SSc-sarcoidosis
- SSc-sarcoidosis prevalence
- 0.30%
ILD
- Tended to be more frequent with SSc-sarcoidosis; differences not significant
Pulmonary hypertension
- Tended to be more frequent with SSc-sarcoidosis; differences not significant
Abnormal nailfold capillaries
- Tended to be less frequent with SSc-sarcoidosis; differences not significant
Digital ulcers
- Tended to be less frequent with SSc-sarcoidosis; differences not significant
Original publication
Epidemiology and Survival of Systemic Sclerosis–Sarcoidosis Overlap Syndrome. J Rheumatol. Published 1 February 2023. doi:10.
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