Vasculitis & polymyalgia rheumatica
Large vessel involvement in antineutrophil cytoplasmic antibody-associated vasculitis
Authors' conclusion
AAV can involve large arteries, albeit infrequent.
Study context
- Population
- Patients >18 years with large vessel involvement in ANCA-associated vasculitis (AAV) (L-AAV), fulfilling 2022 ACR/EULAR criteria for GPA, MPA or EGPA, ANCA positive, Mayo Clinic, Rochester, 2000–202120 (56%) male
- Participants
- 36 patients
- Outcome
- Features of patients with L-AAV
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- p-ANCA and/or MPO-ANCA
- 23
- c-ANCA and/or PR3-ANCA
- 13
- Mean (SD) age at AAV diagnosis, years
- 63.4 (12.79)
- Large vessel vasculitis and AAV diagnosed within 1 year
- 25, 69%
- Histopathological confirmation of AAV in a location other than temporal artery, aorta or periaortic soft tissue
- 25 (69%)
- Treatment: GC
- 36/36
- Treatment: RTX
- 19/36
- Treatment: MTX
- 18/36
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Large vessel involvement in antineutrophil cytoplasmic antibody-associated vasculitis. Rheumatology (Oxford). Published 6 September 2023. doi:10.
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