Vasculitis & polymyalgia rheumatica
Prior polymyalgia rheumatica is associated with sonographic vasculitic changes in newly diagnosed patients with giant cell arteritis
Main finding · LVV on USResult — go to the resultOdds ratio 7.65 95% CI 2.72–23.97Authors' conclusion
Patients with a diagnosis of PMR before GCA diagnosis had two times more often large vessel involvement and significant more vasculitic stenoses on ultrasound examination than patients without prior PMR. Pre-existing PMR is an independent risk factor for more extensive and advanced ultrasound findings at GCA diagnosis.
Study context
- Population
- Newly diagnosed GCA patients, diagnosed December 2006 to May 2021, vascular US49 (15.8%) with prior PMR
- Participants
- 311 participants
- Exposure
- GCA with prior PMR vs without prior PMR
- Prior PMRn = 49
- Outcome
- Vascular US findings: presence of vasculitis (LVV) and vascular stenosis
- Follow-up
- GCA diagnosis
Methodological detailsmultivariable analysis
- Multivariable analysis
Main finding
LVV on US
Odds ratio
7.65
95% CI 2.72–23.97
P < 0.001
By group
Prior PMRvs No prior PMR
OR 7.65 (95% CI 2.72–23.97); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Stenosis within vasculitic segments on US
P < 0.001
Large vessel vasculitis (LVV) by polymyalgic symptoms at GCA diagnosis (patients without prior PMR)
- Polymyalgic symptoms at GCA diagnosis not associated with higher prevalence of LVV
- P = 0.156
Original publication
Prior polymyalgia rheumatica is associated with sonographic vasculitic changes in newly diagnosed patients with giant cell arteritis. Rheumatology (Oxford). Published 30 August 2023. doi:10.
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