Vasculitis & polymyalgia rheumatica
Macrovascular damage in polymyalgia rheumatica: integrated vascular phenotyping in the POLYMYACARD cohort
Authors' conclusion
Patients with PMR exhibited increased aortic stiffness and elevated carotid pulsatility and resistance in the ECA compared with controls, independent of traditional CV risk factors.
Study context
- Population
- Patients with PMR (POLYMYACARD cohort) and controls26 PMR also had GSUS/CDUS
- Exposure
- PMR vs controls
- PMRn = 72
- Outcome
- Macrovascular damage: aortic stiffness (cfPWV) and carotid GSUS/CDUS markers
Methodological detailscontrolled, multivariable linear regression, propensity score matching
- Controlled
- Multivariable linear regression
- Propensity score matching
Main finding
As reported in the abstract
Vascular markers, PMR vs controls (after multivariable linear regression (MLR) and PSM)
- PMR vs Controls: padj=0.012
- PMR vs Controls: padj=0.020
- PMR vs Controls: padj=0.027
Observational data: associations, not effects.
Further findings
Subclinical arteriosclerosis prevalence (PSM)
adjusted p = 0.028
- Subclinical arteriosclerosis prevalence (propensity score matching (PSM)): 13/16 vs. 7/16
Plaque area, elevated CRP vs not (PMR)
- Plaque area greater with elevated CRP: 0.41 (0.13-1.07) vs. 0.05 (0.00-0.31); p = 0.016
Correlations with age
- Carotid-femoral pulse wave velocity (cfPWV), p < 0.001
- r = 0.588
- Carotid intima-media thickness (cIMT), p = 0.004
- r = 0.542
- Plaques, p < 0.001
- r = 0.662
Correlations with mean arterial pressure
- cfPWV, p = 0.038
- ρ = 0.247
- cIMT, p = 0.020
- r = 0.515
- Plaques, p = 0.006
- r = 0.596
Original publication
Macrovascular damage in polymyalgia rheumatica: integrated vascular phenotyping in the POLYMYACARD cohort. Arthritis Res Ther. Published 15 September 2026. doi:10.
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