Vasculitis & polymyalgia rheumatica
Do statins decrease vascular inflammation in patients at risk for large-vessel vasculitis? A retrospective observational study with FDG-PET/CT in polymyalgia rheumatica, giant cell arteritis and fever of unknown origin
Authors' conclusion
Our preliminary results suggest that statins may exert a potential protective role on vascular inflammation in patients with PMR and GCA.
Study context
- Population
- Patients with PMR, giant cell arteritis (GCA) and fever of unknown origin who underwent FDG-PET/CT75 (58.1%) with large-vessel vasculitis (LVV)
- Participants
- 129 patients
- Exposure
- Statin use vs no statin use
- Statinsn = 20
- Outcome
- FDG-PET/CT-assessed vascular inflammation (TVS)
Methodological detailsFDG-PET/CT
- FDG-PET/CT
Main finding
As reported in the abstract
Total vascular score (TVS)
- Total vascular score (TVS) significantly lower in patients treated with statins
- Statins vs No statins: P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Vascular inflammation by site: aorta and femoral arteriesStatins vs No statins · aorta; lower with statins | P = 0.023 |
| Vascular inflammation by site: aorta and femoral arteriesStatins vs No statins · femoral arteries; lower with statins | P = 0.027 |
Original publication
Do statins decrease vascular inflammation in patients at risk for large-vessel vasculitis? A retrospective observational study with FDG-PET/CT in polymyalgia rheumatica, giant cell arteritis and fever of unknown origin. Clin Exp Rheumatol. Published 18 April 2023. doi:10.
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