Vasculitis & polymyalgia rheumatica
Immunopathological features of myopathy associated with small-to-medium-sized vessel vasculitis and differences from autoimmune myositis
Authors' conclusion
Patients with vasculitis demonstrated mild myofiber damage based on the lower involvement of CD56/NCAM-expressing myofibers compared to those with AIM. Complement component deposits on the vessel walls and hypervascularity in the endomysium areas may be immunopathological features of vasculitic myopathy.
Study context
- Population
- Patients with small-to-medium-sized vessel vasculitis and patients with autoimmune myositis (AIM) undergoing muscle biopsy
- Participants
- 15 vs 15
- Exposure
- Small-to-medium-sized vessel vasculitis vs AIM
- Vasculitisn = 15
- AIMn = 15reference
- Outcome
- Immunopathological features of skeletal muscle
Methodological detailsmuscle biopsy immunohistochemistry, disease controls
- Muscle biopsy immunohistochemistry
- Disease controls
Main finding
As reported in the abstract
C5b-9/MAC deposits in blood vessels in vasculitis
>70%
Observational data: associations, not effects.
Original publication
Immunopathological features of myopathy associated with small-to-medium-sized vessel vasculitis and differences from autoimmune myositis. Clin Exp Rheumatol. Published 9 April 2023. doi:10.
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