Vasculitis & polymyalgia rheumatica
Protein Profiling in Presymptomatic Individuals Separates Myeloperoxidase–Antineutrophil Cytoplasmic Antibody and Proteinase 3–Antineutrophil Cytoplasmic Antibody Vasculitides
Authors' conclusion
To our knowledge, this is the first study to identify protein markers preceding symptom onset in AAV patients.
Study context
- Population
- Individuals later diagnosed with AAV identified via the National Patient Register and Cause of Death register linked to 5 biobanks, with samples collected before symptom onsetreplication: 48 cases, 96 controls
- Comparison
- Presymptomatic AAV vs matched controls
- Presymptomatic AAVn = 85
- Outcome
- Levels of inflammation-related proteins (Olink Inflammation panel, 73 of 92 proteins) in presymptomatic samples
- Follow-up
- Before symptom onset
Methodological detailspresymptomatic biobank samples, 2 matched controls per case, replication cohort, Olink Inflammation panel
- Presymptomatic biobank samples
- 2 matched controls per case
- Replication cohort
- Olink Inflammation panel
Main finding
As reported in the abstract
Of the 20 proteins with the lowest P values in the original cohort, replicated in the second cohort
7
Proteins significant between the groups in a meta-analysis
5
Pathways in network enrichment analyses significant in both cohorts
11
Observational data: associations, not effects.
Further findings
Samples obtained ≤5 years before symptom onset (subgroup)
- Significant levels of CCL23, VEGF-A and hepatocyte growth factor; increased at borderline significant levels in the replication cohort
- IL-6 significantly increased in the replication cohort
Proteins associated with antineutrophil cytoplasmic antibody (ANCA) positivity in presymptomatic AAV
- Proteins associated with MPO-ANCA positivity
- 6
- Proteins associated with PR3-ANCA positivity
- 7
Original publication
Protein Profiling in Presymptomatic Individuals Separates Myeloperoxidase–Antineutrophil Cytoplasmic Antibody and Proteinase 3–Antineutrophil Cytoplasmic Antibody Vasculitides. Arthritis Rheumatol. Published 9 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →